Friday, June 29, 2012
Not Funny...secondary side effects
Taking a myriad of drugs for other side effects is just rediculous
The following are suggestions only: take them with a grain of salt and research them thoroughly.
I recommend Protandim.... 100% natural, 0% side effects, proven to work 100% for everyone, every time!
:)
What is it good for? Well... it reduces oxidative stress by 40% in 30 days... The same oxidative stress that is linked to more than 200 diseases and disorders... Find out more here:
www.Nrf2Therapy.com
:)
What is it good for? Well... it reduces oxidative stress by 40% in 30 days... The same oxidative stress that is linked to more than 200 diseases and disorders... Find out more here:
www.Nrf2Therapy.com
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John Butz This product has milk thistle in it, be careful if you are taking bloodthinner such as coumidin, I had an almost fatal reaction to milkthistle in a supplement I took briefly several years ago, was in the hospital fo two weeks.
Ufuk Sepin-Curtis John, the Milk Thistle in Protandim is contains 80% silymarin and it's effects on people with blood thinners have been well studied. Please see the response from the corporate site to this subject below:- Ufuk Sepin-Curtis Can people take Protandim while taking Coumadin or other blood thinners?
Yes, people on Coumadin can take Protandim without interference. If they test their own clotting time, they should test a day or two after starting Protandim to make ...See More - Ufuk Sepin-Curtis It sounds like some people on blood thinner meds need to test their own clotting time before and after they start with Protandim to make sure to understand whether an adjustment in Coumadin dosage is needed. Of course the best thing is to check with your doctor first.
- Ufuk Sepin-Curtis Thank you for bringing that to other readers attention though. I have posted a FAQ section under the notes tab in this page where this information is shared as well.
Powerful Microscope
New technology breaks the theoretical limit on how small we can see
Posted 03.01.2011 at 2:40 pm11 Comments
SEM Comparison Section A shows a microsphere superlens image of a commercial Blu-Ray DVD disc. The 100-μm-thick transparent protection layer of the disc was peeled off before applying the microsphere. The 100-nanometer lines (top left SEM image) are seen by the microsphere superlens at top right. Section B shows an image of a star structure made for the film covering the Blu-Ray disc. The SEM is at 500 nanometers; the optical microscope is at 5 micrometers. Li and Wang, University of Manchester
A new microscope combines a normal optical scope with a see-through microsphere superlens, beating the diffraction limit of light and shattering the limits of optical microscopes.
With the new method, there is theoretically no limit on how small an object researchers will be able to see. It could potentially see inside human cells and examine live viruses for the first time.
The standard optical microscope can only see items down to about one micrometer. To see things in the nanoscale, researchers use methods like scanning tunneling microscopes, scanning electron microscopes, transmission electron microscopy and atomic force microscopy.
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Technology, Rebecca Boyle, adaptive optics,dna, electron microscope, health, images,microscopes, microscopic analysis,nanotechnology, optics, viruses
The new method works by integrating a microsphere “superlens” with a traditional optical microscope. The spheres magnify images of items that are placed on the microscope plate, touching the microsphere and forming “virtual images,” according to authors Zengbo Wang, Wei Guo and Lin Li of the University of Manchester, UK. The optical microscope magnifies the virtual images, forming a greatly enhanced image.
“The microspheres are in contact with objects, and the microscope must focus below the object surface to capture the image. This is a very different practice from the normal use of microscopes,” Li said in an e-mail.
Optical diffraction limits dictate that the smallest object that can be seen is around half the optical wavelength. For visible light, this is about 200 nanometers to 700 nanometers. That means the smallest thing you can actually see is about 200 nanometers — pretty small, but not small enough to resolve interesting molecules and cells.
The new method allowed Li and colleagues to see objects at 50 nanometers, he said.
“This clearly breaks the theoretical optical imaging limit,” he said.
Microsphere Microscope: Li and Wang, University of Manchester
It also overcomes some drawbacks associated with electron microscopes. A TEM sends a beam of electrons through an object, interacting with it as they pass through it. The device forms an image of this interaction and magnifies it. An SEM scans an object with a high-energy electron beam, which also interacts with the sample. The interaction can provide information about the object’s topography and composition. An STM applies a voltage very close to an object, allowing electrons to tunnel through the space between them. This current can be monitored as the voltage tip moves across the object, and is translated into an image. And an AFM essentially feels a surface using a mechanical probe.
Optical fluorescence microscopes can see inside cells by dyeing them, but it can’t penetrate viruses, and it would be nice to see cells without having to inject them with dye. What’s more, the electron methods involve chemical reactions that must be accounted for. Last year, for instance, IBM researchers made an AFM image of a molecule to figure out its chemical composition, but some scientists wondered whether the measuring method itself interfered with the molecule’s structure. It required putting the molecule on a salt crystal, but if no one knew the shape to begin with, they can’t know whether the salt affects the shape.
So it would be nice if you could just take a look at something and see it for yourself. This new method will allow that to happen — imaging viruses, DNA and molecules in real time.
The method uses optical near-field images, which has no diffraction limit, Li said. Near-field images are within the optical wavelength of the optics involved. Far field is beyond that distance.
“Therefore, theoretically, there is no limit on how small we can see. It will depend on how much can we amplify the image using the spheres and relay it to the far field,” Li said.
The team's paper is published in the journal Nature Communications.
Nanotube Cancer Tech
Posted 11.02.2007 at 12:11 pm0 Comments
Scientists conducting pre-clinical trials have shownthat tiny nanotubes, heated up with radio waves, can destroy cancer cells while leaving healthy cells relatively unharmed. The tests, performed in rabbits, showed that the radio-nanotube technique fries the cancer completely, and without side effects.
The next trick, according to the group, is figuring out how to deliver those nanotubes to the right spot. They need to ensure that they attach to tumor cells, and not the healthy kind. The scientists suggest that clinical trials of the technique, a continuation of work begun by nanotech pioneer Richard Smalley before his 2005 death, are at least three years away.—Gregory Mone
Rats Immune to Cancer-mole rats
Naked Mole Rats Immune to Cancer
The naked mole rat is immune to cancer. At last, scientists have figured out why
Posted 10.27.2009 at 1:44 pm44 Comments
Mole Pile
Naked mole rats are unique in many ways. For one, they're the only mammals with a hive mind, obeying their queen as if they were ants. Also, they feel no pain, an adaptation still not fully understood. But most importantly for us, they are the only animals that don't get cancer.
And now, a new study by scientists at the University of Rochester, New York, explains at last why these horrific animals, of all of the world's creatures, are immune to cancer.
According to the scientists, the mole rat's cells express a gene that tells cells to stop dividing. The gene, called p16, forms a second ring of defense against cancer. Most mammals, including humans, only have one gene, p27, protecting cells from cancer. And while most cancers know a way around p27, p16 stops them cold.
In the experiment, researchers gave cancer to a mole rat cell. However, unlike similarly altered mouse cells, the cancerous mole rat cell didn't engage in the non-stop proliferation associated with cancer.
Naked mole rats were already known for their extreme longevity, living much longer than other similarly sized rodents. This was thought to result from their ability to massively slow down their metabolism during times of privation, but this immunity to cancer almost certainly also contributes to their long lifespans.
Some other mole rat facts: their lips are behind their front teeth, they breathe mostly through their skin, and acid doesn't really burn them. I don't know what planet these things are from, but if they're helping cure cancer, I'm glad they're here.
Chip Organs
Living organ-on-a-chip could soon replace animal testing
- By Sebastian Anthony on June 22, 2012 at 8:03 am
- 7 Comments
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If a team of Harvard bioengineers has its way, animal testing and experimentation could soon be replaced by organ-on-a-chip technologies. Like SoCs (system-on-a-chip), which shoehorn most of a digital computer into a single chip, an organ-on-a-chip seeks to replicate the functions of a human organ on a computer chip.
In Harvard’s case, its Wyss Institute has now created a living lung-on-a-chip, a heart-on-a-chip, and most recently a gut-on-a-chip.
We’re not talking about silicon chips simulating the functions of various human organs, either. These organs-on-a-chip contain real, living human cells. In the case of the gut-on-a-chip, a single layer of human intestinal cells is coerced into growing on a flexible, porous membrane, which is attached to the clear plastic walls of the chip. By applying a vacuum pump, the membrane stretches and recoils, just like a human gut going through the motions of peristalsis. It is so close to the real thing that the gut-on-a-chip even supports the growth of living microbes on its surface, like a real human intestine.
In another example, the Wyss Institute has built a lung-on-a-chip, which has human lung cells on the top, a membrane in the middle, and blood capillary cells beneath. Air flows over the top, while real human blood flows below. Again, a vacuum pump makes the lung-on-a-chip expand and contract, like a human lung.
These chips are also quite closely tied to the recent emergence of the lab-on-a-chip (LoC), which combines microfluidics (exact control of tiny amounts of fluid) and silicon technology to massively speed up the analysis of biological systems, such as DNA. It is thanks to LoCs that we can sequence entire genomes in just a few hours — a task that previously took weeks or months.
These human organs-on-a-chip can be tested just like a human subject — and the fact that they’re completely transparent is obviously a rather large boon for observation, too. To test a drug, the researchers simply add a solution of the compound to the chip, and see how the intestinal (or heart or lung) cells react. In the case of the lung-on-a-chip, the Wyss team is testing how the lung reacts to possible toxins and pollutants. They can also see how fast drugs (or foods) are absorbed, or test the effects of probiotics.
Perhaps more importantly, these chips could help us better understand and treat diseases. Many human diseases don’t have an animal analog. It’s very hard to find a drug that combats Crohn’s disease when you can’t effectively test out your drug on animals beforehand — a problem that could be easily solved with the gut-on-a-chip. Likewise, it is very common for drugs to pass animal testing, but then fail on humans. Removing animal testing from the equation would save money and time, and also alleviate any ethical concerns.
Moving forward, the Wyss Institute, with funding from DARPA, is currently researching a spleen-on-a-chip. This won’t be used for pharmaceutical purposes, though; instead, DARPA wants to create a “portable spleen” that can be inserted into soldiers to help battle sepsis (an infection of the blood).
And therein lies the crux: If you can create a chip that perfectly mimics the spleen or liver or intestine, then what’s to stop you from inserting those chips into humans and replacing or augmenting your current organs? Instead of getting your breasts enlarged, you might one day have your liver enlarged, to better deal with your alcoholism. Or how we connect all the organ chips together and create a complete human-on-a-chip?
Pig Lung transplants for humans coming
Posted 02.11.2010 at 12:35 pm19 Comments
Hog head, the deadliest food at the banquet fiskfisk, via Flickr.com
With the world facing an organ shortage so serious that the majority of potential transplant recipients die while on waiting lists, doctors have looked to similarly sized animal organs as a potential alternative to human donations. Unfortunately, the human body swiftly rejects animal organs. Animal lungs have proven especially problematic, as they stop functioning as soon as they com in contact with human blood.
Now, researchers at Alfred Hospital in Melbourne, Australia, have used genetically modified pig lungs to successfully pump human blood. Since pig organs are essentially the same size and shape as human organs, this advance could drastically increase the number of lungs available for transplant.
The lungs themselves were created at St. Vincent's Hospital, also in Melbourne. There, doctors removed DNA, known as the Gal gene, known to hinder inter-species compatibility. At Alfred Hospital, the doctors hooked the lungs up to artificial breathing machines, and watched as deoxygenated human blood pumped through the pig lungs, and came out oxygen rich on the other end.
However, even though this advance represents a series leap forward, the scientists themselves to expect to begin clinical trials of the new technique for at least another five to ten years.
Injectable Oxygen: emergency life extension
http://www.popsci.com/science/article/2012-06/injecting-oxygen-filled-microparticles-bloodstream-could-buy-half-hour-suffocating-patients
Injecting Oxygen Directly into the Bloodstream Could Save Suffocating Patients
Posted 06.27.2012 at 3:42 pm6 Comments
Oxygenating Blood With Microparticles Researchers have developed microparticles packed with oxygen that can be injected into the bloodstream in cases where the lungs cannot properly oxygenate the blood, buying medical personnel as much as an extra half hour before the patient suffers the effects of oxygen deprivation. Courtesy Children's Hospital Boston
When a person stops breathing--be it from an obstruction in the airway or something like acute lung failure--the clock is decidedly ticking. Deprived of oxygen for long enough, a person can go into cardiac arrest. Brain damage sets in. Without oxygen, things go south pretty quickly. So a team of researchers at Boston Children’s hospital has designed a kind of injectable oxygen that can be quickly introduced to a person’s bloodstream to oxygenate the blood, buying paramedics or other medical personnel perhaps as much as half an hour to remedy an oxygen flow problem.
The microparticle solution is different than blood substitutes, which do carry oxygen but need to be oxygenated by the lungs. These new microparticles consist of a single thin layer of lipids that encase a tiny bubble of oxygen gas. These particles are delivered to the bloodstream via injection in a liquid solution and can return a deoxygenated blood supply in vivo to near normal levels in a matter of seconds. And if a person gets in a situation where he or she needs this kind of therapy, seconds definitely count.
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Science, Clay Dillow, first aid, health, medicine,microparticles, triage
But quash all visions of injecting oneself with a steady dose of oxygenated particles and living indefinitely in an oxygen free environment. The oxygen is encased in lipids--basically fatty molecules--and carried in a solution that would overload the blood in high enough doses, causing a range of other biological complications that would make lack of oxygen just one problem among many. Still, 15-30 minutes isn’t bad if you’re at the receiving end. The microparticles are portable, so given the right approvals every EMT, crash cart, transport helicopter, ambulance, police officer, firefighter, and clinician could keep a syringe full of oxygen particles handy, allowing them to quickly stabilize patients until some other life-saving technology, like a breathing tube, can more permanently rectify the situation.
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