Talking with two biologists people today I heard of an unusual treatment (bacteria milkshake)to a major bacterial killer in older people called C.Diff (bacterial infection of the lower colon).
This treatment is called a "fecal transplant". Read real curative stories below:
This infection is difficult to get rid of and can be resistant to antibiotics and often occurs after normal antibiotics are used. Basically the C.Diff bacteria is resistant to normal antibiotics. Normal, psotive bacteria in the lower gutt that has a wide area presence holds it's ground until normal antibiotics kill it off mistakenly. This normal territory becomes open ground for C.Diff to take over and repopulate in mass, quickly becoming the dominate bacteria (negative kind), this leads to infection, major diarrehea from large lower color basterial colonies.
A biologist was able to heal an older person with this type of resistant infection by performing a novel therapy........he took a HEALTHY PERSON'S poop/feces that was FULL OF POSITIVE BACTERIA IN HIGH NUMBERS, MADE A MILKSHAKE AND INJECTED IT UP INTO THE SICK PERSON'S COLON. He re-introduced the positive bacteria in large numbers into the sick patient's colon to TIP-THE-BALANCE towards the positive symbiotic bacteria and win the war against the C.Diff infection. This CURED the patient and drove out the C.Diff. I will list several cures in the next post.
Bacterial Therapy: (Wikipedia Reprint)
See definition below:
C.Diff (as known in the medical field....common infection in older adults)
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This treatment is called a "fecal transplant". Read real curative stories below:
This infection is difficult to get rid of and can be resistant to antibiotics and often occurs after normal antibiotics are used. Basically the C.Diff bacteria is resistant to normal antibiotics. Normal, psotive bacteria in the lower gutt that has a wide area presence holds it's ground until normal antibiotics kill it off mistakenly. This normal territory becomes open ground for C.Diff to take over and repopulate in mass, quickly becoming the dominate bacteria (negative kind), this leads to infection, major diarrehea from large lower color basterial colonies.
A biologist was able to heal an older person with this type of resistant infection by performing a novel therapy........he took a HEALTHY PERSON'S poop/feces that was FULL OF POSITIVE BACTERIA IN HIGH NUMBERS, MADE A MILKSHAKE AND INJECTED IT UP INTO THE SICK PERSON'S COLON. He re-introduced the positive bacteria in large numbers into the sick patient's colon to TIP-THE-BALANCE towards the positive symbiotic bacteria and win the war against the C.Diff infection. This CURED the patient and drove out the C.Diff. I will list several cures in the next post.
Bacterial Therapy: (Wikipedia Reprint)
Theoretical basis
The hypothesis behind fecal bacteriotherapy rests on the concept of bacterial interference, i.e using harmless bacteria to displace pathogenic organisms. This approach to combating bacterial infections is not new[12] and has long been used in animals, for example, to prevent salmonellosis in chickens[13]. In the case of CDI, the C.difficile pathogen is identifiable. However in the case of pseudomembranous colitis, whilst C. difficile is the most common cause, there are other C. difficile-negative pseudomembranous colitis cases. In patients with relapsing CDI, the mechanism of action may be the restoration of missing components of the flora including Bacteroidetes and Firmicutes[14][15][16]. The introduction of normal flora results in durable implantation of these components[17]. Another theoretical mechanism entails the production of antimicrobial agents (Bacteriocins) by the introduced colonic flora to eradicate C.difficile. This may be a similar mechanism to that of Vancomycin which originated from soil bacteria, and bacillus thuringiensis which has been proven to produce bacteriocins specific for C. difficile[18]. The potential combination of replacement of missing components and production of antimicrobial products manufactured by the incoming flora are likely to be the mechanisms curing CDI. In the case of ulcerative colitis, no single 'culprit' pathogen has been identified in humans. However since C.difficile colitis responds so well to FMT, it is conceivable that ulcerative colitis may respond in a similar fashion, where the offending infective agent/s are still unknown. It is also possible that an infection persists but cannot be identified as was the case with pseudomembranous colitis when it was first treated in 1958[6].
[edit]Benefits
Benefits of FMT include the restoration of the colonic microbiota to its natural state by replacing missing Bacteroidetes and Firmicutes species, eradication of C. difficile, and resolution of clinical symptoms such as diarrhea, cramping and urgency. Antibiotic resistance in CDI is an uncommon event- rather CDI relapses due to the presence of C. difficile spores[19]. Although once considered to be 'last resort therapy' by some medical professionals due to its unusual nature and 'invasiveness' compared with antibiotics; perceived potential risk of infection transmission; and lack of Medicare coverage for donor stool, the recent position statement by specialists in infectious diseases and other societies[1] is moving away from FMT as a last-resort treatment and toward acceptance of FMT as standard therapy for relapsing CDI and also Medicare coverage in the United States. Indeed the Editor-In-Chief of the Journal of Clinical Gastroenterology, Dr Martin Floch, announced in a recent editorial that "FMT using donor stool has arrived as a successful therapy"[20]. Given that antibiotics are the original cause of CDI through their damage of the normal human flora and removal of protective Bacteroidetes and Firmicutes species, further antibiotic therapy should be avoided. It has now been recommended that endoscopic Fecal Microbiota Transplantation be elevated to first-line treatment for patients with clinical deterioration and severe relapsing C. difficile infection[5]. The earlier the infusion is initiated, the less likely the patient's condition will deteriorate, thereby preventing the higher mortality rate associated with severely affected patients. Fecal Microbiota Transplantation is being increasingly used in clinical practice and since complications of FMT are so rare its use is likely to increase exponentially in the coming years.
[edit]History
The first description of FMT was published in 1958 outlining the successful treatment of four patients with pseudomembranous colitis before C. difficile was the known cause[6]. Since that time sporadic cases have appeared in the literature. However FMT has been developed in more recent years by Thomas J Borody and his team at the Centre for Digestive Diseases (CDD) in Sydney, Australia, primarily as an alternative treatment for CDI, including pseudomembranous colitis. Given that CDI develops following damage to the colonic flora with antibiotics, FMT appears the most logical choice for CDI cure.
At the CDD there were indications that FMT could benefit other conditions including ulcerative colitis[21][22], autoimmune disorders[23], neurological conditions[24], obesity, metabolic syndrome and diabetes[10], and Parkinson's disease[25]; research continued. The future of FMT is likely to move away from crude, homogenised human flora and progress towards the use of highly refined stool, comprising bacteria only and mixed with a cryoprotectant to be frozen and stored for usage. Ultimately such an extract can be dried, powdered and encapsulated to be administered as an enteric coated medication for use in a number of flora-related conditions.
See definition below:
C.Diff (as known in the medical field....common infection in older adults)
Clostridium difficile (C. difficile) is a bacterium that is related to the bacterium that cause tetanus andbotulism. The C. difficilebacterium has two forms, an active, infectious form that cannot survive in the environment for prolonged periods, and a nonactive, "noninfectious" form, called a spore, that can survive in the environment for prolonged periods. Although spores cannot cause infection directly, when they are ingested they transform into the active, infectious form.
C. difficile spores are found frequently in:
- hospitals,
- nursing homes,
- extended care facilities, and
- nurseries for newborn infants.
They can be found on:
- bedpans,
- furniture,
- toilet seats,
- linens,
- telephones,
- stethoscopes,
- fingernails,
- rings (jewelry),
- floors,
- infants' rooms, and
- diaper pails.
They even can be carried by pets. Thus, these environments are a ready source for infection with C. difficile.
What is Clostridium difficile (C. difficile) colitis?
Antibiotic-associated (C. difficile) colitis is an infection of the colon caused byC. difficile that occurs primarily among individuals who have been usingantibiotics. It is the most common infection acquired by patients while they are in the hospital. More than three million C. difficile infections occur in hospitals in the US each year. After a stay of only two days in a hospital, 10% of patients will develop infection with C. difficile. C. difficile also may be acquired outside of hospitals in the community. It is estimated that 20,000 infections with C. difficile occur in the community each year in the U.S.
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Clostridium difficile (klos-TRID-e-uhm dif-uh-SEEL), often called C. difficile or C. diff, is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. Illness from C. difficile most commonly affects older adults in hospitals or in long term care facilities and typically occurs after use of antibiotic medications.
In recent years, C. difficile infections have become more frequent, more severe and more difficult to treat. Each year, tens of thousands of people in the United States get sick from C. difficile, including some otherwise healthy people who aren't hospitalized or taking antibiotics.
Mild illness caused by C. difficile may get better if you stop taking antibiotics. Severe symptoms require treatment with a different antibiotic.
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